well it depends. are you on a boat or on the shore? if you are on a boat, it will depend on your tolerance to the waves (sea sickness) and your water crafts limits... so, if it is a small boat, then you probably don't want to be out during a small craft advisory. If you are on the shore... then really it is worth a try. Depending on your bait you may get lucky still. For example if you are fishing with something like a 'cajun thunder' bobber that makes a lot of noise to attract fish in the wavy conditions, maybe you will get lucky, but, it all depends on if there are fish were you are fishing and if they are hungry enough to go for what you throw out there.